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. 2021 Aug 19;9(8):e003031. doi: 10.1136/jitc-2021-003031

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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CBS inhibits cell viability and promotes apoptosis of HCC cells. (A–C) The knockdown efficiency of CBS in Hep3B cells (A) and overexpression efficiency of CBS in MHCC97H (B) and Hepa1-6 cells (C), respectively. (D–F) The effect of CBS knockdown on Hep3B cell viability (D) and the effect of CBS overexpression on MHCC97H (E) and Hepa1-6 cell viability (F) were detected by using CCK-8 assay, respectively. (G–L) Flow cytometry was used to determine apoptosis of Hep3B, MHCC97H and Hepa1-6 cells, and representative images were shown in G, I and K. In A–L, data are represented as mean±SEM, and statistical significance was calculated by Student’s two-tailed t-test (A–C and H, J and L) or two-way ANOVA analysis (D–F). *P<0.05; **p<0.01; ***p<0.001. ANOVA, analysis of variance; CBS, cystathionine β-synthase; HCC, hepatocellular carcinoma.