PsA patients report low health-related quality of life (HRQoL) influenced by different disease related factors such as disability, disease activity, pain, particular comorbidities, and musculoskeletal manifestations.

Most available studies on the role of the different factors associated to HRQoL in PsA patients are based on cross-sectional methodologies not considering its evolution over a follow-up period or how it is influenced by different disease variables.

The objective of this study is to analyze the influence of several clinical aspects, comorbidities, and medications in the evolution of HRQoL in PsA patients followed-up in a rheumatology clinic in Spain.

Our study revealed that older age, a previous diagnosis of obesity, and the presence of enthesitis were significantly associated with worse HRQoL at baseline. Presence of enthesitis also resulted in worse HRQoL during the follow-up, while methotrexate or antimalarial treatments were significantly associated with an improvement of this condition.

Study findings point to musculoskeletal manifestations and comorbidities as the main factors associated with a worse HRQoL evolution, thus suggesting that an optimal management of the disease needs to properly address these points.