| Why carry out this study? |
| The association between IgG4-related disease (IgG4-RD) and malignancy remains controversial. |
| This study aims to evaluate the prevalence of malignancies in a multicenter cohort of Chinese IgG4-RD patients and to identify the potential related factors of malignancy. |
| What was learned from the study? |
| We reported a significantly increased prevalence of malignancies in IgG4-RD patients. |
| Eosinophil percentage and autoimmune pancreatitis are potential risk factors, whereas serum albumin-to-globulin ratio (AGR) is negatively associated with malignancy in IgG4-RD. |
| A nomogram for assessment of malignancy in IgG4-RD patients was first developed and validated. |
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