. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: Transl Res. 2021 May 23;236:87–108. doi: 10.1016/j.trsl.2021.05.003

Table II.

Classification of sensory neurons from adult mouse DRGs and markers¹²⁸

Neuron size	Small neurons						Large neurons
Principal neuron types Classical markers	PEP Tac1, Calca		NP IB4, P2 × 3, Plxnc1			TH Th	NF Nefh, Ldhd
Subpopulations	PEP1	PEP2	NP1	NP2	NP3	-	NF1	NF2	NF3	NF4	NF5
Myelinated/unmyelinated	Unmyelinated	Myelinated	Unmyelinated			Unmyelinated	Myelinated
Gene markers/products	TRPV1	Nav1.8/9	TRPA1	TRPV1	TRPV1	TRPA1	TrkB^high	TrkB^low	TrkC^high	TrkC^low	TrkC^low
Gene markers/products	Nav1.8/9	TrkA	TRPC3	TRPA1	TRPA1	NAV1.8/9	NEFH	RET	RET	ASIC1	ASIC1
	TrkA	CGRP	MRGPRD	TRPC3	TRPC3	VGLUT3		NEFH	NEFH	CNTNAP2	CNTNAP2
	CGRP	Fam19A1	P2 × 3	Nav1.8/9	Nav1.8/9	Piezo2				NEFH	NEFH
	PLXNC1^low	NEFH		MRGPRA3	P2 × 3
Gene expression/subtype	Plxnc1	Fam19a1⁺	P2 × 3^hgh	Ntrk1⁺	Sst⁺	Th⁺	Ntrk2^high Necab2	Ntrk2^low	Ntrk3^hgh	Ntrk3^low
	Tac1⁺	Calca⁺		Calca⁺	P2 × 3^low	Plxnc1⁻		Calb1	Pv⁻	Pv⁺
	Calca⁺	Nefh⁺				Ntrk1⁻			Fam19a1⁺	Fam19a1⁻
						Nefh⁻				Cntnap2⁺
										Spp1⁺
Modality-specific function	Peptidergic		Nonpeptidergic			C-LTMRs	AS-LTMRs	Aβ-LTMRs (RA, SA)		Proprioceptors

Abbreviations: ASIC1, acid sensing ion channel subunit 3; Aβ-LTMRs (RA, SA), alpha beta low threshold mechanoreceptor (rapidly adapting or slowly adapting); Aδ-LTMRs, alpha-delta low-threshold mechanoreceptor; Calb1, calbindin 1; Calca, calcitonin-related polypeptide-α; CGRP, calcitonin gene-related peptide; C-LTMRs, C-low threshold mechanoreceptors; Cntnap2⁺, contactin associated protein 2-positive; Fam19A1, family with sequence similarity 19 member A1; IB4, isolectin-B4; Ldhd, lactate dehydrogenase B; MRGPR, Mas-related G-protein coupled receptor member; Nav1.8/9, voltage-gated sodium (NaV) channels 1.8/1.9; Necab2, N-terminal EF-hand calcium binding protein 2; Nefh, neurofilament heavy; NF, neurofilament-positive; NP, nonpeptidergic; PEP, peptidergic; Piezo2, piezo type mechanosensitive ion channel component 2; Plxnc1, plexin C1; Pv, parvalbumin; P2 × 3, P2X purinoceptor 3; RET, RET proto-oncogene; Spp1⁺, secreted phosphoprotein 1; Sst⁺, somatostatin-positive; Tac1, tachykinin precursor 1; TH/Th, tyrosine hydroxylase; Trpa1, transient receptor potential ankyrin 1; Trpc3, transient receptor potential cation channel subfamily C member 3; Trpv, transient receptor potential cation channel; Trk, tyrosine receptor kinase; VGLUT3, vesicular glutamate transporter 3.