. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: Transl Res. 2021 May 23;236:87–108. doi: 10.1016/j.trsl.2021.05.003

Table IV.

Type 2 diabetes models with delayed healing and known evidence of neuropathy

Model	Comments	References
Mouse models
B6.Cg-Lep^ob/J (ob/ob)	Very obese, high glucose and insulin levels	^282–285
Monogenic JAX stock #000632
BTBR-ob/ob	Very obese, high glucose and insulin levels	^286–289
Monogenic	Retinopathy
JAX stock #004824	Nephropathy
BKS.Cg-Dock7^m +/+ Lepr^db/J (db/db)	Very obese, high glucose and insulin levels	^290–293
Monogenic	Myocardial disease
JAX stock #000642
C57BL/6J diet-induced obese	Less obesity than genetic models and moderate increase in glucose and insulin	^294–299
JAX stock # 380050	Hypertension Endothelial dysfunction
Rat models
Zucker diabetic fatty (ZDF)	Obese, high glucose and insulin levels	^300–305
Monogenic	Hydronephrosis and hypertension
Otsuka Long-Evans Tokushima fatty	Late onset obesity and increases in glucose and insulin levels (moderate range)	^303,304
Polygenic
Zucker diabetic Sprague-Dawley (ZDSD/Pco)	Obesity and early onset high glucose and insulin	^305,306
Polygenic	Osteoporosis and nephropathy	^307–309
Goto-Kakizaki	Not obese	^307–309
Polygenic	High glucose and insulin
High-fat diet-low dose streptozotocin (STZ)-treated	Obesity, high glucose and insulin Retinopathy Renal dysfunction Cardiomyopathy	^310–312