Table 3.0.

Positive effects, adverse effects, and withdrawal symptoms associated with tianeptine use that appeared at least once in Reddit posts made between 2011–2020

Positive effects	Adverse effects	General withdrawal symptoms	Specific withdrawal symptoms
Improved mood.	Tolerance.	Flu-like.	Tremors.
Increased energy.	Tolerance develops rapidly.	General withdrawal symptoms.	Muscle aches.
Increased productivity.	Physical dependence.	Severe opioid withdrawal.	Restless legs.
Mental focus, alertness, clarity, memory	Mild physical dependence.	Painful opioid withdrawal.	Restless Leg
Increased motivation.	Addiction.		Syndrome.
Feelings of contentedness.	Opioid effect is strong enough to precipitate relapse to harder opioids.		Sweating.
Stimulant.			Hot flashes.
Analgesic/pain relief.			Fever.
Anxiolytic.	Gut pain.		Nausea.
Anti-depressant.	Gnawing gut pain.		Vomiting.
Mood stabilizing.	Diarrhea.		Incontinence.
Mood enhancing.	Nausea.		Drowsiness.
Effective at mitigating general opioid withdrawal.	Vomiting.		Fatigue.
	Constipation.		Negative affect.
Substitutes well for buprenorphine.	Light-headedness.		Depression.
Effective at mitigating fentanyl withdrawal.	Nodding off.		Anxiety.
	Fatigue.
Euphoria, intoxication.	Low motivation, sluggishness.
Opioid-like effects.	Difficulty sleeping.
Nodding off.	Makes kratom inert.
Relaxation.	Unfavorable interaction with memantine.
Anti-asthmatic.
Good at potentiating effects from: cannabis, kratom, amphetamines.	Decreases effectiveness of other drugs; blunts their effectiveness.
Increases socialization/decreases social anxiety.	Little to no positive effect.
	Tastes like nail polish.
Increased otherwise depressed libido.
	Tianeptine sulfate not as effective as tianeptine sodium.
	Tianeptine sodium is shorter lasting than tianeptine sulfate.
	Desired effect wears off too quickly; short-acting; need to dose frequently.
	Anhedonia.
	Negative affect at high doses.
	Depressive symptoms.
	Increased anxiety.
	Severe vein damage from injecting.
	Overdose.
	Downsides unspecified.