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. Author manuscript; available in PMC: 2021 Dec 20.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2021 Apr 24;111:110334. doi: 10.1016/j.pnpbp.2021.110334

Figure 2.

Figure 2.

Biochemical determination of nicotine in the tank water during 14 days exposure (a) and binding studies (b) evaluated at 7 and 14 days after nicotine exposure in the whole brain. 3H-Epi = Epibatidine,125αBgtx = Bungarotoxin. CTR= drug-free group. Data are mean ± SEM of three replicate analyses for nicotine determination and 4 replicates (10 fish each) for binding studies. WDW=withdrawal. **p < 0.01 vs pre and 48 h, #p < 0.05 vs CTR, $ $p < 0.01 vs 1h (one–way ANOVA, Tukey’s test).