Table 1: In Vivo Oral Wound Healing Models.

A review of the literature on oral wound healing published in the past twenty years. Studies were limited to in vivo models that were using therapeutic approaches for oral wound healing. Oral wound healing models were analyzed by injury location, species, strain, sample size, timeline, and defect size. Injury location were primarily in the palatal, buccal, and gingival regions of the oral cavity. Species used to model studies ranged from small animals, as in mice and rat, to larger species like dogs and human. Timeline indicated days or weeks when healing outcomes were recorded, and defect details the injury size and methods by which the injury was created.

Wound Model	Species	Strain	Sample Size	Timeline	Defect Details	Studies
Palatal	Rat	Sprague Dawley	20 18	8 weeks 2, 4, 7 days	1.3mm by 7mm surgical excise 3mm biopsy punch	Li et al. [2019] Zhu et al. [2015]
		Wistar	28 72 20	7, 14 days 3, 5, 7 days 0, 3, 7, 14, 21 days	5mm biopsy punch 4mm biopsy punch 4.5mm biopsy punch	Maeda et al. [2013] Kim et al. [2013] Suragimath et al. [2010]
	Mouse	C57BL/6	11 174	3, 5, 7, 10 days 1, 3, 5, 7 days	1.5mm biopsy punch 1.5 mm cautery excise	Keswani et al. [2013] Ballestas et al. [2019]
	Dog	Beagle	6 16	1, 3, 12 weeks 7, 14 days	6mm biopsy punch 6mm biopsy punch	Ophof et al. [2008] Ayvazyan et al. [2011]
	Minipig	Berlin	7	40 days	15mm biopsy punch	Kesting et al. [2010]
	Piglet	Yorkshire Hybrid	6 18	5 weeks 3, 7, 10, 76 days	10mm biopsy punch 15mm biopsy punch	Kirschner et al. [2006] Rohleder et al. [2013]
	Human	N/A	15	4, 8, 15, 29 days	6mm biopsy punch	Thoma et al. [2012]
Buccal	Rat	Sprague Dawley	56	12, 28 days	75mm2 by iris scissors	Roh et al. [2018]
		Wistar	60 36	1, 3, 7 days 3, 5 days	7mm biopsy forceps 5mm biopsy punch	Couto et al. [2016] Priprem et al. [2018]
	Mouse	Institute of Cancer Research	36	1, 3, 5 days	1.5mm biopsy punch	Shim et al. [2007]
	Rabbit	New Zealand White	36	1, 3, 7, 14 days	10mm surgical excise	Lis et al. [2012]
Gingival	Rabbit	New Zealand White	20 22 36	0, 7, 14 days 5 days 3, 6, 9, 12 days	6mm by 50% acetic acid 15mm surgical excise 5mm by 50% acetic acid	Lim et al. [2016] Kılıç et al. [2013] Karavana et al. [2011]
		Japanese White	24 24	13 days 7, 14 days	5mm by 50% acetic acid 6mm by 50% acetic acid	Umeki et al. [2014] Fujisawa et al. [2003]