Table 2: Regenerative Therapies for Oral Wound Healing.

Oral wound healing models were organized by therapeutic approaches. Studies were analyzed by therapy vehicles, treatment methods, cell/drug used (if any), and outcome measures. Treatments were either synthetic polymer scaffolds, biological-synthetic combination scaffolds, biologically derived grafts, or fluid-like gel/topical ointment. Outcome measures ranged from qualitative analysis through gross observations and histology to quantitative analysis using flow cytometry and qPCR.

Therapy Vehicle	Treatment Matrix	Cell/Drug/Growth Factor	Outcome Measures	Studies
Polymer Scaffold	Chitosan disc	Glutathione	Histology, GSH levels, malondialdehyde levels, nitric oxide levels	Kılıç et al. [2013]
	PLGA/PCL electrospun nanofiber	FTY720	Histology, IHC, flow cytometry, ELISA, serum sodium, qPCR	Ballestas et al. [2019]
	Carboxyvinyl polymer and trolamine	Curcumin	Gross observation, histology	Lim et al. [2016]
Biopolymer Scaffold	Decellularized amnion membrane with POC		Gross observation, histology, body weight, CT scanning, IHC	Li, et al [2019]
Biological Graft	Collagen-gelatin sponge	bFGF	Gross observation, histology; IHC	Ayvazyan et al. [2011]
	Oral mucosal cell sheets	Keratinocytes, Fibroblasts	Gross observation, histology, IHC	Roh et al. [2018]
	Collagen matrix (Mucograft®)		Gross observation, somatosensory measurements	Thoma et al. [2012]
	Human amnion membrane; Collagen-based dermal matrix (Integra®)		Gross observation, histology, IHC	Kesting et al. [2010]
	Amniotic membrane allograft; small intestinal submucosa; autofetal amniotic membrane		Gross observation, histology	Rohleder et al. [2013]
	Dermal substrates (DED and AlloDerm™)	Keratinocytes	Histology, IHC, heparan sulphate	Ophof et al. [2008]
	Acellular human dermal graft (AlloDerm™)		Gross observation, histology	Kirschner et al. [2006]
	Cellmatrix	Leptin	IHC, RT-PCR, wound healing assay, ELISA	Umeki et al. [2014]
	Fibrin glue	Keratinocyte	Gross observation, histology	Lis et al. [2012]
Gel/ Topical Ointment	10% niosome gel	Anthocyanin	Gross observation, histology, XANES, EXAFS	Priprem et al. [2018]
	Hydrochloride gel	Benzydamine	Gross observation, histology	Karavana et al. [2011]
	Lectin Artin M gel		Histology, IHC, ELISA	Kim et al. [2013]
	Saline solution	Bismuth subgallate	Histology, IHC	Couto et al. [2016]
	Hyaluronan ointment	Dimethyloxalylglycine	Gross observation, histology	Zhu et al. [2015]
Injection	N/A	EGF, bFGF	Gross observation, histology	Fujisawa et al, [2003]
	N/A	Aucubin	Gross observation, histology	Shim et al. [2007]
	N/A	VEGF	Histology, IHC, ELISA	Keswani et al. [2013]
Alternative Therapy
	Carbonated drink		Gross observation, histology	Suragimath et al. [2010]
	Low-intensity pulsed ultrasound		Gross observation, histology	Maeda et al. [2013]