Table 3: Analyzing the Signatures of Oral Wound Healing.

Oral wound healing studies were organized by injury model, therapeutic approach, and main treatment method. Success of regenerative therapy was evaluated by comparison of research outcomes to current hallmarks of oral wound healing. Studies were assessed by wound closure, angiogenesis, cell/gene proliferation, epithelial thickness, inflammatory response, and collagen deposition. Positive sign denotes a reported increase in respective category, and negative sign represents a decrease in outcome following main treatment.

Studies	Model	Therapy Vehicle	Main Treatment	Wound Closure	Blood Vessel/Angiogenesis	Cell / Gene Proliferation	Epithelial Thickness	Inflammatory Response	Collagen Deposition
Ballestas et al. [2019] Ayvazyan et al. [2011] Li et al. [2019] Ophof et al. [2008] Kesting et al. [2010] Kirschner et al. [2006] Rohleder et al. [2013] Thoma et al. [2012] Zhu et al. [2015] Kim et al. [2013] Keswani et al. [2013] Maeda et al. [2013] Suragimath et al. [2010] Roh et al. [2018] Lis et al. [2012] Couto et al. [2016] Priprem et al. [2018] Shim et al. [2007] Lim et al. [2016] Kılıç et al. [2013] Umeki et al. [2014] Karavana et al. [2011] Fujisawa et al. [2003]	Palatal	Polymer Scaffold	PLGA/PCL electrospun nanofibers with FTY720 Collagen-gelatin sponge with bFGF	+ +	+	+	+	−
		Biopolymer Scaffold	Decellularized amnion membrane and POC	+	−	+	+		+
		Biological Graft	Dermal substrates (DED and AlloDerm™) Human amnion membrane (Integra®) Acellular human dermal graft (AlloDerm™) Amniotic membrane allograft Collagen matrix (Mucograft®)	+ + + +	+		+ +		+ +
		Gel/Ointment	Hyaluronan ointment with dimethyloxalylglycine Lectin Artin M gel	+ +	+	+ +	+	−	+
		Injection	VEGF	+	+	+
		Other	Low-intensity pulsed ultrasound Carbonated drink	+ −			−		−
	Buccal	Biological Graft	Oral mucosal cell sheets with keratinocyte and fibroblasts Fibrin glue with keratinocyte	+ +
		Gel/Ointment	Bismuth subgallate 10% niosome gel with anthocyanin	+	−			+	=
		Injection	Aucubin	+				−	+
	Gingival	Polymer Scaffold	Carboxyvinyl polymer and trolamine with curcumin Chitosan disc with glutathione	+	+		+	+
		Biological Graft	Cellmatrix with leptin	+	+	=
		Gel	Hydrochloride gel with Benzydamine	+	+
		Injection	bFGF	+		+

+ Analyzed and Increase

− Analyzed and Decrease

= Analyzed and Inconclusive

Blank Did Not Analyze