Table 3: Analyzing the Signatures of Oral Wound Healing.
Oral wound healing studies were organized by injury model, therapeutic approach, and main treatment method. Success of regenerative therapy was evaluated by comparison of research outcomes to current hallmarks of oral wound healing. Studies were assessed by wound closure, angiogenesis, cell/gene proliferation, epithelial thickness, inflammatory response, and collagen deposition. Positive sign denotes a reported increase in respective category, and negative sign represents a decrease in outcome following main treatment.
| Studies | Model | Therapy Vehicle | Main Treatment | Wound Closure | Blood Vessel/Angiogenesis | Cell / Gene Proliferation | Epithelial Thickness | Inflammatory Response | Collagen Deposition |
|---|---|---|---|---|---|---|---|---|---|
|
Ballestas et al. [2019]
Ayvazyan et al. [2011] Li et al. [2019] Ophof et al. [2008] Kesting et al. [2010] Kirschner et al. [2006] Rohleder et al. [2013] Thoma et al. [2012] Zhu et al. [2015] Kim et al. [2013] Keswani et al. [2013] Maeda et al. [2013] Suragimath et al. [2010] Roh et al. [2018] Lis et al. [2012] Couto et al. [2016] Priprem et al. [2018] Shim et al. [2007] Lim et al. [2016] Kılıç et al. [2013] Umeki et al. [2014] Karavana et al. [2011] Fujisawa et al. [2003] |
Palatal | Polymer Scaffold | PLGA/PCL electrospun nanofibers with FTY720 Collagen-gelatin sponge with bFGF |
+ + |
+ |
+ |
+ |
− | |
| Biopolymer Scaffold | Decellularized amnion membrane and POC | + | − | + | + | + | |||
| Biological Graft | Dermal substrates (DED and AlloDerm™) Human amnion membrane (Integra®) Acellular human dermal graft (AlloDerm™) Amniotic membrane allograft Collagen matrix (Mucograft®) |
+ + + + |
+ |
+ + |
+ + |
||||
| Gel/Ointment | Hyaluronan ointment with dimethyloxalylglycine Lectin Artin M gel |
+ + |
+ |
+ + |
+ |
− |
+ |
||
| Injection | VEGF | + | + | + | |||||
| Other | Low-intensity pulsed ultrasound Carbonated drink |
+ − |
− |
− |
|||||
| Buccal | Biological Graft | Oral mucosal cell sheets with keratinocyte and fibroblasts Fibrin glue with keratinocyte |
+ + |
||||||
| Gel/Ointment | Bismuth subgallate 10% niosome gel with anthocyanin |
+ |
− | + | = | ||||
| Injection | Aucubin | + | − | + | |||||
| Gingival | Polymer Scaffold | Carboxyvinyl polymer and trolamine with curcumin Chitosan disc with glutathione |
+ |
+ |
+ |
+ |
|||
| Biological Graft | Cellmatrix with leptin | + | + | = | |||||
| Gel | Hydrochloride gel with Benzydamine | + | + | ||||||
| Injection | bFGF | + | + |
+ Analyzed and Increase
− Analyzed and Decrease
= Analyzed and Inconclusive
Blank Did Not Analyze