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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Addict Biol. 2021 Feb 23;26(6):e13024. doi: 10.1111/adb.13024

Figure 3. Comparison of nicotine metabolite levels following passive vapor or intravenous nicotine self-administration (IVSA) in female rats.

Figure 3.

Blood samples were collected at baseline (pre-nicotine) or following 1 hr sessions of either nicotine vapor (5 mg/ml) or IVSA (0.03 mg/ml/infusion) from female rats (n=6/group). (A) Female cotinine levels were decreased following passive nicotine vapor exposure for all time-points, as compared to IVSA nicotine. *p<0.05, **p<0.01, ***p<0.001 passive vapor vs. IVSA. (B) Females did not differ in the amount of nicotine self-administered between Day 1 and Day 7. Data are presented as mean ± SEM.