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. 2021 Aug 9;12:698734. doi: 10.3389/fendo.2021.698734

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Copyright © 2021 Zhang, Liu, Lv, Zhang, Hu, Li, Ma, Cui and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma lipid profiles of the general offspring born to PCOS women (n_PCOS-off =70) or healthy control women (n_Con-off =71). (A, B) PLS-DA scores plot established the relationship model between the metabolite expression and the sample category, which indicated different metabolites profile between PCOS-off and Con-off in the positive (A) and negative (B) polarity modes. (C, D) Volcano plot of p values and fold change between PCOS-off and Con-off summarized the distribution of the differential lipids in the positive (C) and negative (D) polarity modes. P value was calculated using student t tests; VIP value represents variable importance in the projection value from PLS-DA model. Red, green, and gray dots represent metabolites with up-regulation, down-regulation, or no difference between study groups, respectively. PCOS-off, offspring born to PCOS women; Con-off, offspring of the control group.