Figure 2.

Manhattan plot showing significance of association between differential metabolites and clinical phenotypes. The x-axis represents metabolites differed between PCOS-off and con-off. The y-axis represents the -log₁₀ p value. P value was obtained from the linear regression equation and then performed FDR correction. Dots with different shapes represent different phenotypes, and different colors represent different models. (A) Association between differential metabolites and clinical phenotypes in the general offspring (n_phenotype=2, n_metabolites=44). (B) Association between differential metabolites and clinical phenotypes in the female offspring (n_phenotype=5, n_metabolites=44). (C) Association between differential metabolites with clinical phenotypes in the male offspring (n_phenotype=5, n_metabolites=46). Glucoside^* refers to (1’x,2S)-2-(1,2-Dihydroxy-1-methylethyl)-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one 2’-glucoside.