Table 2.
Clinical characteristics of the general offspring born to women with or without PCOS.
| Characteristics | PCOS-off (n=70) | Con-off (n=71) | P value |
|---|---|---|---|
| BW, g | 3404.0 ± 570.8 | 3423.2 ± 446.4 | 0.82 |
| GA, week | 39.0 (38.0-40.0) | 39.0 (38.0-40.0) | 0.90 |
| Height Z-score | 0.3 ± 0.9 | 0.5 ± 0.8 | 0.27 |
| Weight Z-scorea | 0.3 ± 1.0 | 0.7 ± 1.1 | 0.03* |
| BMI Z-score | 0.2 (-0.5-0.6) | 0.4 (-0.5-1.3) | 0.10 |
| DBP, mmHg† | 58.0 (54.0-60.0) | 58.0 (52.0-60.0) | 0.51 |
| SBP, mmHg† | 90.0 (88.0-96.0) | 90.0 (88.0-100.0) | 0.46 |
| FSH, IU/L | 1.7 (0.8-2.5) | 1.4 (0.9-2.7) | 0.79 |
| LH, IU/L | 0.1 (0.1-0.1) | 0.1 (0.1-0.1) | 0.31 |
| E2, pg/ml | 5.0 (5.0-5.0) | 5.0 (5.0-5.0) | 0.79 |
| PRL, ng/ml | 11.9 (8.1-14.6) | 11.0 (8.1-16.7) | 0.42 |
| T, ng/dl | 2.5 (2.5-2.5) | 2.5 (2.5-2.5) | 0.38 |
| TSH, uIU/ml | 2.9 (2.1-3.4) | 2.9 (2.3-4.4) | 0.11 |
| AMH, ng/ml† | 4.9 (2.9-15.2) | 4.5 (2.5-15.7) | 0.82 |
| DHEA-S, ug/dl | 7.3 (3.3-14.3) | 9.2 (3.9-21.3) | 0.37 |
| FT3, pmol/L | 6.85 ± 0.87 | 6.8 ± 0.8 | 0.73 |
| FT4, pmol/L | 18.2 ± 1.9 | 18.1 ± 2.2 | 0.76 |
| A-TG, IU/ml | 10.8 (10.0-14.1) | 10.7 (10.0-14.2) | 0.80 |
| A-TPO, IU/ml | 8.4 (5.7-10.6) | 8.6 (5.9-11.7) | 0.63 |
| BG0, mmol/L† | 5.0 ± 0.4 | 4.9 ± 0.4 | 0.66 |
| INS0, mIU/L§ | 4.3 (3.0-6.2) | 4.4 (2.9-6.6) | 0.47 |
| HOMA-IR§ | 1.0 (0.7-1.3) | 1.0 (0.6-1.6) | 0.56 |
| HOMA-β§ | 59.5 (40.0-81.2) | 64.7 (50.9-96.5) | 0.12 |
| CHOL, mmol/L† | 4.1 (3.6-4.8) | 4.0 (3.7-4.3) | 0.44 |
| TG, mmol/L† | 0.7 (0.6-0.9) | 0.7 (0.6, 1.0) | 0.33 |
| LDL, mmol/L† | 2.5 (2.1-3.0) | 2.4 (2.1-2.7) | 0.26 |
| HDL, mmol/L† | 1.3 ± 0.3 | 1.3 ± 0.2 | 0.93 |
Data were shown as mean ± SD, median (interquartile range).
Differences were assessed using Student t test or Mann-Whitney U tests for continuous variables and Chi-square tests for categorical variables.
The linear regression was performed to exclude the potential confounding effects of maternal age and BMI [P-adjusted, 0.026; β (95%CI), -0.18 (-0.69, -0.05)].
*p<0.05 was considered statistically significant. †represents a missing data. §represents two missing data.
PCOS-off, offspring born to PCOS women; Con-off, offspring of the control group; BW, birth weight; GA, gestational age; BMI, body mass index; DBP, diastolic blood pressure; SBP, systolic blood pressure; FSH, follicle-stimulating hormone; LH, luteinizing hormone; E2, estrogen; PRL, prolactin; T, Testosterone; TSH, thyroid-stimulating hormone; AMH, anti-Mu ¨llerian hormone; DHEA-S, dehydroepiandrosterone sulfate; FT3, free triiodothyronine; FT4, free thyroxine; A-TG, antibodies against thyroglobulin; A-TPO, antibodies against thyroperoxidase; BG0, fasting glucose; INS0, fasting insulin; HOMA-IR, homeostasis model for insulin resistance; HOMA-β, homeostasis model for β-cell function; CHOL, total cholesterol; TG, triglycerides; LDL, low density lipoprotein cholesterol; HDL, high density lipoprotein cholesterol.