TABLE 2.

The performance of NICS versus TE-PGT on detecting chromosomal abnormalities after the exclusion of MAC embryos.

Embryo	N	Assay	Sensitivity % (95% CI)	Specificity % (95% CI)	NPV % (95% CI)	PPV % (95% CI)
MAC embryos identified by TE-PGT excluded	246	TE-PGT	89.0 (80.9–93.9)	82.6 (75.8–87.7)	92.8 (87.2–96.0)	75.0 (66.1–82.2)
MAC embryos identified by NICS excluded	238	NICS	85.7 (77.1–91.5)	79.6 (72.4–85.3)	90.0 (83.6–94.1)	72.2 (63.1–79.8)
MAC embryos identified by PGT/NICS excluded	229	TE-PGT	89.7 (81.5–94.5)	82.4 (75.3–87.8)	92.9 (87.0–96.2)	75.7 (66.6–83.0)
		NICS	87.4 (78.8–92.8)	80.3 (73.0–86.0)	91.2 (84.9–95.0)	73.1 (63.8–80.7)
		p	0.7905	0.7359	0.6495	0.7505

The performance was assessed by comparing with the CNV from the whole embryo assay as the gold standard. NPV, negative predictive value; PPV, positive predictive value; MAC, multiple abnormal chromosomes.