Table 1.
Selectins expression and the enzymes required for PSGL-1 binding.
| Type of ligand | Expressed on Cell/Tissue | References | Reported Glycosyl- and sulfotransferases involved in selectin-ligand biosynthesis |
|---|---|---|---|
| P-selectin | Choroid plexus | (50) | Fucosyltransferase-VII (FucT-VII), Fucosyltransferase-IV (FucT-IV), Core 2 β1,6-glucosaminyltransferase (C2GlcNAcT-I), Sialyl 3-galactosyltransferase (ST3Gal), β1,4-galactosyltransferase (β1,4GalT-I), Tyrosine protein sulfotransferases 1,2 (TPST1,2) |
| Lung endothelium | (51) | ||
| Platelets | (52) | ||
| Platelet-derived microparticles | (53) | ||
| Peritoneal macrophages | (54) | ||
| Inflamed endothelium | (55, 56) | ||
| E-selectin | Skin endothelium | (57) | Fucosyltransferase-VII (FucT-VII), Fucosyltransferase-IV (FucT-IV), Sialyl 3-galactosyltransferase (ST3Gal) |
| Inflamed endothelium | (55) | ||
| L-selectin | Myeloid cells | (55) | Fucosyltransferase-VII (FucT-VII), Fucosyltransferase-IV (FucT-IV), Core 2 β1,6-glucosaminyltransferase (C2GlcNAcT-I), Sialyl 3-galactosyltransferase (ST3Gal), Tyrosine protein sulfotransferases 1,2 (TPST1,2) |
| Naive T-cells | (55) | ||
| Effector T-cells | (58) | ||
| Effector memory T-cells | (58) | ||
| Central memory T-cells | (58) | ||
| Monocytes | (59) | ||
| Neutrophils | (60) |