Table 2.
Evaluation and outcomes during hospitalization.
| All Patients (N = 92) | AKI group (N = 22) | Non-AKI group (N = 70) | P value (&) | |
|---|---|---|---|---|
| Patients with MIS-C | 28 (30%) | 15 (68%) | 13 (19%) | <0.001 |
| Median duration of hospital stay in days (Range) | 3 (1–43) | 9.5 (1–43) | 3 (1–16) | <0.001 |
| Patients admitted to the ICU (%) | 34 (37) | 20 (91) | 14 (20) | <0.001 |
| Median duration of ICU stay in days for patients admitted to the ICU (Range) | 4.5 (1–25) | 7.5 (1–25) | 2.5 (1–11) | 0.025 |
| ECMO | 2 (2%) | 2 (9%) | 0 | 0.011 |
| Median peak serum creatinine (Range) (mg/dL) | 0.60 (0.2–4.25) | 1.1 (0.55–4.25) | 0.45 (0.2–0.9) | <0.001 |
| Median lowest serum albumin (Range) (g/dL) | 3.5 (1.7–6.0) | 2.5 (1.7–5.0) | 3.8 (2.3–6.0) | <0.001 |
| Median peak CRP (Range) (mg/L) | 114 (5–450) | 276 (37–450) | 69 (5–348) | <0.001 |
| Median peak CPK (Range) (U/L) | 127 (21–12149) | 282 (21–12149) | 122 (32–315) | 0.213 |
| Median d-dimer (Range) (mg/L) | 3 (0.23–35) | 5.15 (1.7–22) | 1.82 (0.23–35) | 0.002 |
| Median fibrinogen (Range) (mg/dL) | 595 (189–860) | 627 (362–860) | 469 (189–860) | 0.025 |
| Median peak BNP (Range) (pg/mL) | 491 (16–5277) | 2221 (491–5277) | 90 (16–1396) | <0.001 |
| Median troponin (Range) (ng/L) | 40 (3–5880) | 425 (3–5880) | 11 (3–168) | <0.001 |
| Abnormal Urinalysise | 14 (23%) | 8 (47%) | 6 (13%) | 0.005 |
| Inotropic support | 17 (19%) | 13 (59%) | 4 (6%) | <0.001 |
| Mechanical Ventilation | 14 (15%) | 7 (32%) | 7 (10%) | 0.013 |
| Nephrotoxic Medications Received@ | 51 (55%) | 15 (68%) | 36 (51%) | 0.167 |
| ECHO∞ | <0.001 | |||
| Normal EF (≥55%) | 23 (60%) | 7 (37%) | 16 (84%) | |
| Mildly decreased EF (41–54%) | 13 (34%) | 10 (53%) | 3 (16%) | |
| Moderately decreased EF (31–40%) | 1 (1.5%) | 1 (5%) | 0 | |
| Severely decreased EF (≤ 30%) | 1 (1.5%) | 1 (5%) | 0 | |
| Final Outcome | ||||
| Death | 0 | 0 | 0 | |
| Discharge Home | 92 (100%) | 22 | 70 |
&
Comparison between AKI (N = 22) and non-AKI (N = 70) patients for univariate analysis.
e
N = 62 for overall cohort, N = 17 for AKI group and N = 45 for non-AKI group.
@
Nephrotoxic medications included vancomycin, acyclovir, and ibuprofen.
∞
N = 38 for overall cohort, N = 19 for AKI group, and N = 19 for non-AKI group.
MIS-C, Multisystem Inflammatory Syndrome in Children; CRP, C-Reactive Protein; CPK, creatine phosphokinase; BNP, brain natriuretic peptide; ECHO, Echocardiography; ECMO, extracorporeal membrane oxygenation; EF, Ejection Fraction.