Table 4.
Comparison between MIS-C-AKI and Acute SARS-CoV-2-AKI patients.
| MIS-C-AKI (n = 15) | Acute SARS-CoV-2-AKI (n = 7) | P-value | |
|---|---|---|---|
| Median age in years (Range) | 9 (1.8-17) | 17 (10-21) | 0.002 |
| GENDER | 0.648 | ||
| Male | 8 (53%) | 5 (71%) | |
| Female | 7 (47%) | 2 (29%) | |
| RACE | 1.000 | ||
| AA | 13 (87%) | 6 (86%) | |
| Non-AA | 2 (13%) | 1 (14%) | |
| ETHNICITY | |||
| Hispanic | 0 | 0 | |
| Non-Hispanic | 15 (100%) | 7 (100%) | |
| &BMI in kg/m2 | 0.159 | ||
| Non obese | 10 (71%) | 2 (29%) | |
| Obese | 4 (29%) | 5 (71%) | |
| Co-Morbidities# | 6 (40%) | 7 (100%) | 0.01 |
| Median duration of hospital stay in days (Range) | 10 (4–23) | 8 (1–43) | 0.535 |
| Patients admitted to the ICU (%) | 15 (100) | 5 (71) | 0.09 |
| Median duration of ICU stay in days for patients admitted to the ICU (Range) | 8 (2–21) | 5 (1–25) | 0.210 |
| Median peak serum creatinine (Range) (mg/dL) | 1.11 (0.55–4.25) | 1.11 (0.67–1.17) | 0.574 |
| Median lowest serum albumin (Range) (g/dL) | 2.5 (1.7–5.0) | 2.7 (2.4–4.4) | 0.230 |
| Median peak CRP (Range) (mg/L) | 284 (37.5–450) | 269 (129–431) | 0.900 |
| Median peak CPK (Range) (U/L) | 194.5 (30–1386) | 1074 (21–12149) | 0.536 |
| Median d-dimer (Range) (mg/L) | 5.24 (2.48–22) | 2.87 (1.69–7.16) | 0.197 |
| Median fibrinogen (Range) (mg/dL) | 607 (362–860) | 734.5 (689–780) | 0.417 |
| Median peak BNP (Range) (pg/mL) | 2380 (661–5277) | 491 (491) | 0.200 |
| Median troponin (Range) (ng/L) | 534 (15–5880) | 120 (3–448) | 0.239 |
| Abnormal Urinalysis e | 6 (43%) | 2 (67%) | 0.576 |
| Nephrotoxic medications received@ | 12 (80%) | 3 (42%) | 0.08 |
| ECMO | 2 (13%) | 0 | 1.00 |
| Inotropic Support | 11 (73%) | 2 (29%) | 0.074 |
| Mechanical Ventilation | 5 (33%) | 2 (29%) | 1.00 |
|
ECHO∞ Normal EF (≥ 55%), Mildly decreased EF (41-54%) Moderately Decreased EF (31-40%) Severely Decreased EF (≤ 30%) |
5 (33%) 8 (53%) 1 (7%) 1 (7%) |
2 (50%) 2 (50%) 0 0 |
0.602 |
&
BMI not calculated for one patient in MIS-C-AKI group due to age <24 months.
#
Co-Morbidities as defined in Methods.
€ N = 14 for MIS-C-AKI group and N = 3 for Acute SARS-CoV-2-AKI group.
@
Nephrotoxic medications included vancomycin, acyclovir, and ibuprofen.
∞
N = 15 for MIS-C-AKI group and N = 4 for Acute SARS-CoV-2-AKI group MIS-C, Multisystem Inflammatory Syndrome in Children; CRP, C-Reactive Protein; CPK, creatine phosphokinase; BNP, brain natriuretic peptide; ECHO, Echocardiography; ECMO, extracorporeal membrane oxygenation; EF, Ejection Fraction.