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CD45 gene polymorphism and disease consequences. C77G and A138G are the two CD45 polymorphisms affecting PTPRC gene in human. While C77G target exon four splice silencer which affects the expression of CD45RO and leads to immune disorders such as multiple sclerosis and HIV infection, A138G polymorphism is a substitution of exon six and results in high expression of CD45RO with subsequent immune disorders such as hepatitis B infection and Grave’s disease.
