Table 7.
OR and Adjusted or (95% CI) of Thyroid Dysfunction Among Chemical and Organic Workers with CPY, NAT2, and PON1 Polymorphisms
| Gene | Allele | OR (95% CI) | Adjusted OR* (95% CI) | ||||
|---|---|---|---|---|---|---|---|
| All Workers | Chemical Workers | Organic Workers | All Workers | Chemical Workers | Organic Workers | ||
| CYP1A1 | AA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| rs1048943 | AG/GG | 1.32 (0.73–2.38) | 18.14 –(2.29–143.2) | 0.58 (0.28–1.18) | 1.08 (0.65–3.02) | 15.12 (2.01–134.6) | 0.58 (0.47–2.01) |
| P value | 0.355 | 0.006 | 0.134 | 0.211 | 0.009 | 0.114 | |
| CYP2B6 | AA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| rs2279343 | AG/GG | 2.49 (1.34–4.62) | 16.03 (2.03–126.5) | 1.54 (0.76–3.11) | 1.94 (1.11–5.02) | 14.68 (1.63–145.7) | 1.16 (0.68–3.78) |
| P value | 0.004 | 0.008 | 0.227 | 0.008 | 0.011 | 0.214 | |
| CYP2C19 | GG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| rs4244285 | GA/AA | 3.36 (1.76–6.44) | 12.61 (1.60–49.5) | 2.91 (1.40–6.03) | 3.29 (1.94–4.59) | 10.04 (1.75–78.26) | 2.12 (1.19–4.32) |
| P value | 0.001 | 0.016 | 0.004 | 0.001 | 0.017 | 0.009 | |
| NAT2 | GG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| rs1799931 | GA/AA | 1.78 (0.98–3.21) | 7.59 (1.62–35.35) | 1.39 (0.67–2.85) | 1.21 (0.94–4.02) | 11.02 (2.79–50.36) | 1.23 (0.98–1.87) |
| P value | 0.776 | 0.001 | 0.369 | 0.054 | 0.005 | 0.421 | |
| PON1 | AA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| rs662 | AG/GG | 1.49 (0.82–2.69) | 9.58 (1.21–75.6) | 1.30 (0.64–2.64) | 1.67 (0.69–3.04) | 8.45 (1.99–80.23) | 1.65 (0.67–2.14) |
| P value | 0.187 | 0.032 | 0.453 | 0.204 | 0.041 | 0.514 | |
Notes: OR and Adjusted OR analyzed by Binary logistic regression. *Adjusted for sex, age, smoking status, alcohol consumption, and exposure parameters.
Abbreviations: CI, confidence interval; OR, odds ratio.