Table 5.

Summary of prediction performance of CBCrisk, Manchester formula, and PredictCBC version 1A and version 1B with the corresponding 95% prediction intervals (PI)

Characteristics	CBCriska	Manchester formulab	PredictCBC version 1Ac,d	PredictCBC version 1Bc,d
Discrimination
AUC at 5 years (95% PI)	0.59 (0.54 to 0.64)	0.61 (0.59 to 0.63)	0.63 (0.52 to 0.74)	0.59 (0.46 to 0.71)
AUC at 10 years (95% PI)	0.58 (0.55 to 0.61)	0.60 (0.58 to 0.62)	0.63 (0.53 to 0.72)	0.59 (0.52 to 0.66)
Calibration
E/O ratio at 5 years (95% PI)	0.86 (0.20 to 3.75)	1.54 (0.11 to 20.72)	1.26 (0.14 to 11.34)	1.33 (0.14 to 12.76)
E/O ratio at 10 years (95% PI)	0.82 (0.21 to 3.14)	1.53 (0.13 to 18.52)	1.28 (0.18 to 9.18)	1.35 (0.19 to 10.24)
Slope (95% PI)	1.26 (1.01 to 1.50)	0.39 (0.34 to 0.43)	0.90 (0.73 to 1.08)	0.81 (0.50 to 1.12)

AUC Area under the curve, PI prediction interval

^aChowdhury et al. [7]

^bBasu et al. [8]

^cGiardiello et al. [5], Fig. 1 and Figure S5

^dversion 1A includes BRCA mutation status as a variable while 1B does not