Table 2.
Important patents on the development and application of aptamers in veterinary diagnostics and therapeutics.
| No | Title | Inventors [Country] | Publication Number | Priority Date |
|---|---|---|---|---|
| 1 | Switch mode nucleic acid aptamer probe and uses thereof in detection of tumor living cell and living body | Guo Qiuping et al., [China] | WO2011134328A1 | 2010-04-26 |
| 2 | Nucleic acid aptamer-based diagnostic methods with novel techniques for signal enhancement | Nussbaum Ofer [USA] | WO2012004790A2 | 2010-07-06 |
| 3 | Carcinoembryonic antigen detection kit based on nucleic acid aptamer autocatalysis effect, and preparation method thereof | Zou Mingjing [China] | CN107064505A | 2016-02-18 |
| 4 | Aptamer-directed drug delivery | Bagalkot Vaishali et al., [USA] | WO2007137117A2 | 2006-05-17 |
| 5 | Method for detecting N-hydroxyacetylneuraminic acid content based on aptamer | Gong Sheng et al., [China] | CN108709989A | 2018-05-29 |
| 6 | Nucleic acid aptamer specifically binding to enrofloxacin or ciprofloxacin | Jeong Sang Hee et al., [South Korea] | KR101526921B1 | 2013-06-28 |
| 7 | Aptamer for binding bifidobacterium breve as well as screening method and application of aptamer | Chen Wei et al., [China] | CN105838719A | 2016-04-13 |
| 8 | Serum IgG antibody aptamer of tuberculosis patients and preparation method thereof | Cai Jiangli et al., [China] | CN103045600A | 2011-10-11 |
| 9 | Gene regulation with aptamer and modulator complexes for gene therapy | BUEHLER BERND et al., [UK] | US2005260164A1 | 2002-10-10 |
| 10 | Aptamers for prion diagnostics and aptamer binding detection system | Mohanty Sarina [USA] | WO2014008440A2 | 2012-07-04 |
| 11 | DNA aptamer binding to glyphosate with specificity | Gu Man Bock et al., [South Korea] | KR101338520B1 | 2011-10-25 |
| 12 | Aptamer ELISA detection kit, preparation method, and application thereof | DONG ZAIZAI et al., [China] | CN108957001A | 2018-06-27 |
| 13 | Research and development of aptamer-based rapid detection technology for agricultural veterinary drug residues | Ling Qingyun | CN109596605A | 2017-09-30 |
| 14 | Aptamer specifically binding to nonylphenol and detecting method using thereof | Kim So Youn [South Korea] and Ren Shuo [China] | KR101822881B1 | 2014-03-31 |
| 15 | Biosensing probe kit for detecting sulfadiazine on basis of nucleotide aptamer specificity, and application thereof | Sun Qi et al., [China] | CN107119054A | 2017-05-04 |
| 16 | Aptamer-based multiplexed assays | Katilius Evaldas et al, [USA] | SG10201701361WA | 2012-06-07 |
| 17 | DNA Insulin receptor-specific DNA aptamer and uses thereof | Ahn Ji Young et al., [South Korea] | KR101850793B1 | 2016-07-14 |
| 18 | Target substance detection method using aptamer | Kim So Youn [South Korea] | WO2010093223A2 | 2009-02-16 |
| 19 | Amine-terminated aptamer functionalized surface plasmon resonanace sensors, methods of making and methods of using same | Cameron Brent D et al., [USA] | US9562266B1 | 2012-01-14 |
| 20 | Nucleic acids aptamer binding specifically to cucurbitacin | Choi Tae Young et al., [South Korea] | KR101953994B1 | 2017-09-26 |
| 21 | Use of nucleic acid aptamer in alkaline phosphatase heterodimer recognition and binding or in tumor detection | Bing Tao et al., [China] | WO2019149115A1 | 2018-02-02 |
| 22 | Application of nucleic acid aptamer in recognizing and binding alkaline phosphatase heterodimer | Bing Tao et al., [China] | CN109554369A | 2018-02-02 |
| 23 | Nucleic acid aptamer capable of specifically binding to tetracyclines compound and use thereof | Gu Man Bock et al., [South Korea] | KR101342710B1 | 2012-02-14 |
| 24 | Aptamer nucleic acid probe kit for detecting doxycycline residue as well as preparation method and application thereof | He Hongqiu et al., [China] | CN104360077A | 2014-11-25 |
| 25 | Real-time and continuous measurement in vivo using aptamer-based biosensors | Arroyo Curras Netzahualcoyotl et al., [USA] | WO2017164982A1 | 2016-03-21 |
| 26 | Nucleic acids aptamer binding specifically to Ingenol mebutate | Choi Tae Young et al., [South Korea] | KR101987591B1 | 2018-08-06 |
| 27 | Antigen-binding fragment and/or aptamer for binding to an extracellular part of cd9 and therapeutic uses | Corbeil Denis et al., [USA] | WO2020044285A1 | 2018-08-29 |
| 28 | Escherichia coli o157:h7 aptamer and applications thereof | Amraee Masoum et al.,[Iran] | WO2018189639A1 | 2017-04-15 |
| 29 | Nucleic acid aptamer which specifically binds to bisphenol A | Kim So Youn [South Korea] | EP2397550A2 | 2009-02-16 |
| 30 | Method for detecting mycoplasma gallisepticum antibody of enzyme-linked nucleic acid aptamer and kit special for mycoplasma gallisepticum antibody | Wang Feng and Wu Wenxue [China] | CN109762825A | 2019-03-25 |
| 31 | Target substance detection method using aptamer | Kim So Youn [South Korea] | US2015212038A1 | 2009-02-16 |
| 32 | Nucleic acid aptamer capable of specifically binding to tebuconazole, mefenacet, and inabenfide, and use therof | Gu Man Bock et al., [South Korea] | WO2015056980A1 | 2013-10-16 |
| 33 | Aptamer inhibition of thrombus formation | Li Minyong et al., [China] | AU2009281857A1 | 2008-08-15 |
| 34 | Aptamer-based rapid kanamycin detection test paper as well as preparation method and application thereof | Liu Jing et al., [China] | CN106990237A | 2017-05-10 |
| 35 | Aptamer of enrofloxacin and preparation method and application thereof | Yu Xiaoyan et al., [China] | CN104450725A | 2015-01-05 |
| 36 | Aptamer-coated implant, process of production, and uses | Borck Alexander [Germany] | US2011150964A1 | 2009-12-21 |
| 37 | DNA EGFR-specific DNA aptamer as incubation additives for promotion of mammalian cell growth and uses thereof | Ahn Ji Young et al., [South Korea] | KR101859615B1 | 2016-07-14 |
| 38 | Aptamer-based device for detection of cancer markers and methods of use | Datta Bhaskar et al., [USA] | US2012088232A1 | 2010-09-30 |
| 39 | DNA PDGFR-specific DNA aptamer as incubation additives for promotion of mammalian cell growth and uses thereof | Ahn Ji Young [South Korea] | KR101833231B1 | 2016-07-14 |