Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 9;8:703110. doi: 10.3389/fmolb.2021.703110

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Jiang, Lin, Zhao, Wu, Jin, Yu, Wu, Wu, Wang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Activation and degradation mechanism of ADAMTS5 in vivo. In normal cartilage, ADAMTS5 is activated under the stimulation of inflammatory factors or breakdown products in cartilage ECM. After the removal of its pro-domain by furins, activated ADAMTS5 cleaves the aggrecan core protein at its specific Glu-Xaa recognition motifs. ADAMTS5 can be inhibited by its endogenous inhibitor, TIMP3. ADAMTS5, together with TIMP3 are subsequently endocytosed by chondrocyte via LRP-1 receptor and degraded. Abbreviations: tissue inhibitor of metalloproteinase 3, TIMP3; lipoprotein receptor–related protein 1, LRP-1.