Table 1.
Studies on direct inhibition of Dsg1 and Dsg3 interaction in pemphigus.
| PV | In vitro (cell-free) | In vitro (cultured cells) | In vivo (mice) | Ex vivo (human) |
|---|---|---|---|---|
| Dsg1 |
No inhibition (homophilic): AFM – Heupel, JI 2008 – Walter, Sci Rep 2017 (heterophilic Dsc3): AFM – Spindler, JBC 2009 Inhibition (heterophilic Dsc1): beads – Ishii, JID 2020 No inhibition (homophilic): AFM – Walter, SR 2017 |
No Data |
No Data |
No Data |
| Dsg3 |
Inhibition (homophilic): AFM – Heupel, JI 2008 – Heupel, JBC 2009 – Spindler, JCI 2013 – Walter, SR 2017 Inhibition (heterophilic Dsc3): beads – Ishii, JID 2020 |
Inhibition (homo/heterophilic): AFM – Vielmuth, JID 2015 |
Inhibition No Data |
No Data |
| PF | In vitro (cell-free) | In vitro (cultured cells) | In vivo (mice) | Ex vivo (human) |
| Dsg1 |
No inhibition (homophilic): AFM – Waschke, JCI 2005 Inhibition (heterophilic Dsc1): – Ishii, JID 2020 No inhibition (homophilic): AFM – Walter, SR 2017 |
No inhibition (homo/heterophilic): beads – Waschke, JCI 2005 No inhibition (homo/heterophilic): AFM – Vielmuth, Frontiers Immunol 2018 |
No Data |
No Data |