Table 4.
Frequency of imatinib adverse events
| Adverse events | Grade 1 or 2-% | Grade 3 or 4-% |
|---|---|---|
| Edema€ | 1 (16), 56.4 (40), 62.7 (21), 55.6 (22), 42.8 (12), 22.3 (20) | 7.3 (23), 7.4 (22) |
| Nausea | 21.3 (40), 42.1 (21), 20.4 (22), 42.8 (12), 27.8 (20) | 3.3 (40), 5.6 (22), 7.1 (12) |
| Vomiting | 1.7 (40), 14.8 (22), 42.8 (12) | 5.6 (22), 7.1 (12) |
| Myalgia | 23 (40), 48.2 (22), 5.3 (14), 28.6 (12), 22.3 (20) | 13 (22) |
| Musculoskeletal pain | 37 (40), 57.1 (12) | 3.6 (40) |
| Skin rash | 28.3 (40), 5.3 (14), 16.7 (20) | 6.6 (40) |
| Abdominal pain | 39 (21), 18.5 (22), 21.4 (12), 33.4 (20) | 9.2 (40) |
| Fatigue | 43 (40), 43.8 (21), 30.5 (20) | - |
| Thrombocytopenia | 1.4 (16), 13.3 (40), 10.45 (21) | 3.3 (40) |
| Diarrhea | 0.5 (16), 11.1 (22), 5.5 (20) | - |
| Arthralgia | 10 (40), 50 (22), 5.3 (14), 28.6 (12) | 11.1 (22) |
| Neutropenia | 11.67 (40), 9.3 (21) | 3.3 (40) |
| Ostealgia | 35.2 (22), 5.3 (14) | 13 (22) |
| Muscle cramps | 37 (22), 21.4 (12) | 20.4 (22) |
| Infection | 5 (40), 16.7 (22)β | 3.7 (22)β |
| Weight gain | 18.5 (22), 57.1 (12) | - |
| Headache | 39.5 (21), 25 (20) | - |
| Hemorrhagic events | 17.6 (40)¥, 3.7 (22) | - |
| Anemia | 66.7 (40) | 3.3 (40) |
| Depression | 24 (22) | 5.6 (22) |
| Insomnia | 22.2 (22) | 14.8 (22) |
| Weight loss | 20.4 (22) | 1.85 (22) |
| Constipation | 18.5 (22) | 3.7 (22) |
| Cough | 18.5 (22) | 1.85 (22) |
| Fever | 14.8 (22) | 3.7 (22) |
| Pancytopenia | 14.3 (12) | 14.3 (12) |
| Pruritus | 11.7 (40) | 10 (40) |
| Liver toxicity | 9.6 (40) | 1.9 (40) |
| Dizziness | 21.8 (40) | - |
| Dyspnea | 14.3 (12) | - |
| Red eye | 5 (40) | - |
| Urinary retention | 1.85 (22) | - |
| Leukopenia | 1.2 (16) | - |
€
including peripheral, periorbital, superficial edema and fluid retention,
β
sinusitis and throat infection,
¥
including bleeding tendency and sub-conjunctival hemorrhage