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. 2021 Aug 9;15:695975. doi: 10.3389/fnins.2021.695975

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Copyright © 2021 Fekri Azgomi, Hahn and Faghih.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Wearable brain machine interface architecture. Blood cortisol data is being monitored by a wearable-type device. Analyzing the data collected from the human in the loop, we estimate corticotrophin-releasing hormone (CRH) secretion times that result in cortisol secretion. Then, we estimate a hidden energy state. Finally, the designed control algorithm would determine appropriate time and the dosage of medications, and will result in regulating the energy state in patients with hypercortisolism.