Table 2.
Comparison of Variables between Baseline and 6 Months after the Administration of Dapagliflozin.
| Baseline | 6 months | p value | ||||
|---|---|---|---|---|---|---|
| Clinical Characteristics | ||||||
| Body weight (kg) | 66.5 (56.8-76.9) | 63.9 (56.2-75.6) | <0.001 | |||
| BMI (kg/m2) | 25.3 (23.4-28.8) | 24.9 (22.8-27.8) | <0.001 | |||
| Systolic blood pressure (mmHg) | 130±16 | 128±18 | 0.218 | |||
| Heart rate (bpm) | 71±12 | 70±11 | 0.610 | |||
| BNP (pg/mL) | 27.9 (9.0-58.2) | 28.9 (9.6-62.9) | 0.132 | |||
| BUN (mg/dL) | 14.7 (12.1-19.0) | 17.2 (14.2-21.2) | <0.001 | |||
| Creatinine (mg/dL) | 0.80±0.20 | 0.86±0.23 | <0.001 | |||
| eGFR (mL/min/1.73 m2) | 70.6±17.0 | 65.6±15.3 | 0.001 | |||
| HbA1c (%) | 7.2±0.8 | 7.0±0.8 | 0.108 | |||
| Hemoglobin (g/dL) | 13.7±1.7 | 14.4±1.6 | 0.020 | |||
| Hematocrit (%) | 41.0±4.7 | 43.8±4.5 | 0.002 | |||
| Lipid profiles (mg/dL) | ||||||
| Triglycerides | 127 (84-185) | 116 (82-176) | 0.155 | |||
| LDL cholesterol | 98 (86-118) | 106 (89-126) | 0.078 | |||
| HDL cholesterol | 51.5 (45.0-60.2) | 52 (42.8-65.0) | 0.049 | |||
| Uric acid (mg/dL) | 5.1 (4.4-5.9) | 4.7 (4.2-5.7) | 0.057 | |||
| Echocardiographic Parameters | ||||||
| LV end-diastolic volume (mL) | 74.2 (55.1-104.1) | 68.5 (54.8-93.8) | 0.270 | |||
| LV end-systolic volume (mL) | 24.7 (17.0-54.5) | 20.5 (15.2-57.1) | 0.105 | |||
| LVEF (%) | 62.3 (49.3-68.3) | 63.6 (55.3-71.0) | 0.011 | |||
| LVMI (g/m2) | 75.0 (61.7-92.0) | 67.0 (55.0-81.9) | <0.001 | |||
| LAVI (mL/m2) | 31 (23-45) | 26 (21-32) | 0.001 | |||
| e’ (cm/s) | 6.36±1.73 | 6.82±1.88 | 0.031 | |||
| E/e’ | 9.3 (7.7-11.8) | 8.5(6.6-10.7) | 0.020 | |||
| E (cm/s) | 58.1 (46.8-70.9) | 55.1 (45.3-73.7) | 0.682 | |||
| A (cm/s) | 76.1±17.8 | 75.6±16.8 | 0.765 | |||
| E/A | 0.71 (0.6-0.80) | 0.70 (0.62-0.81) | 0.818 |
Data are mean±SD for normally distributed data and median and interquartile range for non-normally distributed data, or n (%). BNP: plasma brain natriuretic peptide, LDL: low density lipoprotein, HDL: high density lipoprotein, LVMI: left ventricular mass index, LVEF: left ventricular ejection fraction, LAVI: left atrial volume index, E: peak early diastolic mitral flow velocity, e’: spectral pulsed-wave Doppler-derived early diastolic velocity from the septal mitral annulus