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Schematic depicting general organization of the Coronavirus genome. The top panel shows the layout of the two open reading frames (Orf1a and b) and the 3′ structural genes. The bottom panel illustrates that Orf1a and b are divided into 16 genes numbered nsp1–16. Surface rendered models are shown for nsp9 (PDB 6W9Q[6]), holo-RdRp (6XEZ [7]), nsp10/14 (5C8S [8]), nsp13 (6XEZ [7]), nsp15 (6VWW [9]) and nsp10–16 (6W4H [10]).
