Fig. 5.

Nsp9 acts as a substrate for the nsp12 NiRAN. The nsp9 N-terminus snakes into the NiRAN active site proximal to the α/β phosphates of the bound nucleotide (GDP in this case). Conserved NiRAN catalytic residues are depicted as sticks (right inseam). This figure was generated using PDB 7CYQ[65].