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Surface rendered model of the nsp13-RTC [7]. Nsp13 binds to the 5′ t-RNA strand downstream of the RdRp active site. Nsp13 structural domains are highlighted to indicate the domains involved in holo-RdRp and RNA binding (left). Nsp13 translocates on the t-RNA (cyan) in the 5′-3′ direction, whereas the RdRp translocates in the 3′-5′ direction on the t-RNA.
