The independent prognostic factors for COAD OS. (A, C, E) Univariate Cox regression of prognostic factors in the training-, validation- and entire group, respectively. There were statistically significant differences among AJCC stage, T stage, N stage, M stage, and risk score. (B, D, F) Multivariate cox regression of prognostic factors in the training-, validation- and entire group, respectively. AJCC stage and risk score were independent prognostic factors for COAD patients. COAD: colon adenocarcinoma, OS: overall survival, AJCC: American Joint Committee on Cancer.