Table 4.

Primary results, tier 2

	Studies (N)	Cancers (N)	Ref. groupa (N)	OR	95% CI	p value
Tier 2
Overall	11	5081	2904	1.4	(1.1, 1.7)	0.008
Subtypes
Family history
FH + cancers vs noncancers	9	1832	2690	1.6	(1.2, 2.1)	0.002
FH– cancers vs noncancers	9	2352	2690	1.2	(0.9, 1.6)	0.206
FH + vs FH– cancers	10	2079	2584	1.2	(0.9, 1.5)	0.242
Metastatic
M1 cancers vs noncancers	8	497	2410	1.5	(1.0, 2.3)	0.065
M0 cancers vs noncancers	9	3509	2809	1.3	(1.0, 1.7)	0.047
M1 vs M0 cancers	9	504	3910	1.2	(0.8, 1.7)	0.422
Gleason
Gleason ≥8 vs noncancers	11	1234	2904	1.3	(0.9, 1.8)	0.135
Gleason 7 vs noncancers	10	1148	2896	1.5	(1.1, 2.1)	0.008
Gleason ≤6 vs noncancers	11	1937	2904	1.3	(1.0, 1.8)	0.052
Gleason ≥8 vs Gleason ≤6	11	1296	2114	0.9	(0.7, 1.2)	0.384
Aggressive
Agg. vs noncancers	11	2161	2904	1.3	(1.0, 1.8)	0.053
Non Agg. vs noncancers	9	1487	2820	1.4	(1.0, 1.9)	0.058
Agg. vs non-Agg. Cancers	11	2231	1667	0.9	(0.7, 1.2)	0.674
Age at diagnosis
<65 cancers vs noncancers	11	3272	2904	1.3	(1.1, 1.7)	0.018
≥65 cancers vs noncancers	12	1809	2904	1.4	(1.0, 1.9)	0.054
<65 cancers vs ≥65 cancers	12	3710	1728	0.9	(0.7, 1.2)	0.370

Agg. = aggressive; CI = confidence interval; FH = family history; OR = odds ratio; Ref. = reference.

^aControls for case/control analyses. Lower-risk subcategory for case-only analyses.