Table 2.
Mendelian randomization (MR) results
| IVW (slope) | Weighted median (slope) | MR Egger (SIMEX): slope | MR Egger (SIMEX): intercept | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Exposure | Outcome | SNPs | OR | (95% CI) | p | OR | (95% CI) | p | OR | (95% CI) | p | OR | (95% CI) | p |
| ADHD | Major dep. | 10 | 1.21 | (1.12–1.31) | 1 × 10−06 | 1.20 | (1.08–1.33) | 6 × 10−04 | 1.22 | (1.13–1.31) | 1 × 10−03 | 1.00 | 1.00–1.01 | 0.25 |
| Major dep. | ADHD | 3a | 1.80 | (0.85–3.82) | 0.12 | 1.26 | (0.85–1.86) | 0.25 | a | a | a | a | a | a |
| ADHD | Broad dep. | 10 | 1.06 | (0.98–1.15) | 0.14 | 1.01 | (0.96–1.07) | 0.61 | 1.07 | (1.02–1.13) | 0.02 | 1.01 | 1.01–1.01 | 2 × 10−03 |
| Broad Dep. | ADHD | 40 | 1.79 | (1.36–2.36) | 3 × 10−05 | 1.65 | (1.28–2.12) | 1 × 10−04 | 1.76 | (1.32–2.34) | 5 × 10−04 | 1.00 | 1.00–1.01 | 0.30 |
ADHD, attention-deficit/hyperactivity disorder; Dep, depression; IVW, inverse-variance weighted.
Odds ratios for slope estimates estimate the increase in the odds of the outcome for each unit increase in log-odds genetic liability to the exposure. MR Egger intercept measures horizontal pleiotropy.
a
MR Egger (SIMEX) not run due to the small number of SNPs included. No outliers were detected.