Table 3.
Comparison of NASH-CRN histological features identified in NASH, NASH cirrhosis, and hepatitis C cirrhosis.
| Characteristic / N / Comparisons | 1. | 2. | 3. | P | |
|---|---|---|---|---|---|
| Non-cirrhotic NASH N = 7 | Non-specific Cirrhosis N = 7 | Hepatitis C Cirrhosis N = 13 | Group 1 vs. 2 | Group 2 vs. 3 | |
| Macrovesicular steatosis | 0.07 | 0.29 | |||
| Present (> 5%) | 7 | 3 | 2 | ||
| Macrovesicular steatosis | 0.107 | 0.35 | |||
| < 5% | 0 | 4 | 11 | ||
| 5–33% | 4 | 2 | 2 | ||
| 33–66% | 2 | 1 | 0 | ||
| > 66% | 1 | 0 | 0 | ||
| Steatosis distribution | |||||
| Zone 3 | 1 | 0 | 0 | ||
| Zone 1 | 0 | 0 | 0 | ||
| Azonal | 1 | 7 | 10 | ||
| Panacinar | 5 | 0 | 0 | ||
| Microvesicular steatosis | 1.0 | 1.0 | |||
| Present in contiguous patches | 2 | 1 | 1 | ||
| Portal Inflammation | 0.03 | 0.35 | |||
| None | 0 | 0 | 0 | ||
| Mild | 6 | 1 | 0 | ||
| Greater than mild | 1 | 6 | 13 | ||
| Parenchymal Inflammation | 1.0 | 0.51 | |||
| No foci | 0 | 0 | 0 | ||
| < 2 foci per 200x field | 2 | 3 | 3 | ||
| 2–4 foci per 200x field | 3 | 2 | 7 | ||
| > 4 foci per 200x field | 2 | 2 | 3 | ||
| Microgranuloma (present) | 6 | 4 | 2 | 0.56 | 0.12 |
| Large lipogranuloma (present) | 3 | 5 | 8 | 0.60 | 1.0 |
| Ballooned Cells (present) | 7 | 7 | 5 | 1.0 | 0.015 |
| Ballooned Cells (grade) | 1.0 | 0.03 | |||
| None | 0 | 0 | 8 | ||
| Few | 2 | 2 | 2 | ||
| Man | 5 | 5 | 3 | ||
| Acidophil Bodies | 0 | 0 | 6 | 0.05 | |
| Pigmented macrophages | 6 | 5 | 10 | 1.0 | 1.0 |
| Megamitochondria | 2 | 3 | 0 | 1.0 | 0.03 |
| Mallory-Denk Bodies | 4 | 5 | 2 | 1.0 | 0.02 |
| Glycogenated Nuclei | 4 | 4 | 3 | 1.0 | 0.17 |
| Fibrosis Stage | |||||
| 0 | 0 | 0 | 0 | ||
| 1 | 0 | 0 | 0 | ||
| 2 | 3 | 0 | 0 | ||
| 3 | 4 | 0 | 0 | ||
| 4 | 0 | 7 | 13 | ||