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. 2021 Aug 9;12:709240. doi: 10.3389/fimmu.2021.709240

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Copyright © 2021 Amendt, Ayoubi, Linder, Allies, Young, Setz and Jumaa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modulation of immune responses by monovalent antigen requires expression of the IgD-class BCR. (A) Schematic illustrations of a WT and IgD-deficient B cell. (B, C) NP-reactive serum immunoglobulins of WT mice (B) and IgD-deficient mice (C) injected with PBS (control immunization (CI), n=4/group), 4-hydroxy-3-nitrophenylacetyl only (sNP: 1:0; WT n=4, IgD-deficient n=4), complex NP (cNP: 0:1; WT n=7, IgD-deficient n=6) and soluble:complex NP (100:1; WT n=7, IgD-deficient n=5). Left panel showing anti-NP IgM on day 7, right panel shows anti-NP-IgG on day 14. Mean ± SD, students t-tests with Welch’s correction were used to compare two groups within one experiment. **P < 0.01.