Table 3.
Association between PSR and with other measures of the disease
| Years of disease | EDSS | T25-FW | Lesion volume |
BPF | ||
|---|---|---|---|---|---|---|
| T2-Lesion | cBH | |||||
|
| ||||||
| cBH | ||||||
| PSR | −0.53 | −0.63 (p=0.03) | −0.55 | −0.38 | −0.33 | −0.15 |
| Vax | 0.12 | 0.35 | −0.01 | −0.24 | −0.06 | −0.15 |
| Perilesional NAWM | ||||||
| PSR | −0.28 | −0.20 | −0.23 | −0.36 | −0.20 | −0.45 |
| Vax | 0.19 | 0.35 | −0.05 | −0.16 | 0.00 | −0.24 |
| Distant NAWM | ||||||
| PSR | −0.47 | −0.33 | −0.40 | −0.48 | −0.29 | −0.17 |
| Vax | 0.32 | 0.39 | 0.01 | 0.14 | 0.14 | −0.19 |
Values are represented as Pearson correlation coefficient (r) and statistically significant correlation values with the corresponding p value are indicated in bold.
BPF = brain parenchymal fraction; cBH = chronic black hole; EDSS: Expanded Disability Status Scale; NAWM = Normal Appearing White Matter; PSR = macromolecular-to-free pool size ratio; T25-FW = timed 25-foot walk test; Vax = apparent axonal volume fraction.