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. Author manuscript; available in PMC: 2022 Jun 24.
Published in final edited form as: J Med Chem. 2021 Jun 3;64(12):8287–8302. doi: 10.1021/acs.jmedchem.1c00279

Figure 1. Pharmacodynamics and pharmacokinetics of visual cycle modulators.

Figure 1.

A) Visual cycle modulators such as emixustat inhibit RPE65, thus blocking the key trans/cis isomerization step of the visual cycle and reducing the formation of toxic retinaldehyde condensation products. B) Sites of emixustat modification in vivo and strategies to modify its metabolism. C) Three strategies for modifying emixustat metabolism were investigated in this work.