Table 1.
Mannich derived γ-hydroxyamines.
| Compound | * | R | IC50 (nM) | Compound | * | R | IC50 (nM) |
|---|---|---|---|---|---|---|---|
| 23 | S | 4-F | 50 ± 9 | 24 | S | 4-F | 177 ± 11 |
| 25 | R/S | 5-F | 295 ± 132 | 26 | R/S | 5-F | 184 ± 24 |
| 28 | R/S | 6-F | 132 ± 19 | 27 | R/S | 6-F | 157 ± 24 |
| 30 | R/S | 2-F | 274 ± 47 | 29 | R/S | 2-F | 287 ± 28 |
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