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. 2021 Aug 19;11(3):20458940211037274. doi: 10.1177/20458940211037274

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 4. — New therapeutic targets in PH.

SIN3a: switch-independent 3a; TET1: ten-eleven translocase methylcytosine dioxygenase 1; DNMT1: DNA methyltransferase 1; BMPR2: bone morphogenetic protein receptor type 2; PASMCs: pulmonary arterial smooth muscle cells; MCT: monocrotaline; NFU1: mitochondrial iron-sulfur scaffold; FA = fatty acid; ROS: reactive oxygen species; CHK1: checkpoint kinases 1; CHK2: checkpoint kinases 2; sGC β1: soluble guanylate cyclase β1 subunit; cGMP: cyclic 3′5′ guanosine monophosphate; SGLT2: sodium glucose co-transporter 2.