Table 1. Summary of the entire search strategy used for the review.

MeSH: Medical subject heading

Search strategy	Database	Total number of articles	Total number of articles with automation tools	After removal of duplicates and screening	After full screening and quality appraisal
Advanced search: Esketamine OR Intranasal Esketamine OR “Esketamine” [Supplementary Concept] AND Treatment Resistant Depression OR (“Depressive Disorder, Treatment-Resistant/drug therapy”[MesH] OR “Depressive Disorder, Treatment-Resistant/therapy”[MesH])	PubMed	1395	498	14	7
Keyword: Esketamine and Treatment Resistant Depression	Google Scholar	1990	1710	29	3