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. 2021 Aug 23;14:42. doi: 10.1186/s13040-021-00273-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Analysis of differentially expressed genes and differentially methylated sites in GBM Subtypes. Left panel: Gene Enrichment Analysis of downregulated genes (red bars) and hypomethylated CpG sites (blue bars) in each subtype. Vertical lines represent the p-value cutoff (p = 0.05). Middle panel: Volcano Plot, representing differential gene expression (Z-Ratio; red dots) and differentially methylated CpG sites (M-value fold change; blue dots). Horizontal lines indicate the q-value threshold (Student’s t-test, corrected by FDR = 0.05). Right panel: Gene Enrichment Analysis of upregulated genes (red bars) and hypermethylated CpG sites (blue bars) in each subtype, being (A) Classical subtype, B Mesenchymal subtype, and C Proneural subtype. Vertical lines represent the p-value cutoff (p = 0.05)