Fig. 4.

NcRNAs involved in the STAT3 pathway in glioma. NcRNAs and their targets involved in the STAT3 pathway regulate the formation and development of glioma. In glioma, the activation of STAT3 can be induced by growth factors and cytokines. Cytokine or growth factor binding to its receptor can activate JAK through tyrosine phosphorylation. Under the action of JAKs, STAT3 can be activated and form homodimers or heterodimers (STAT1/3) and then enter the nucleus to function as a transcription factor. NcRNAs can regulate the expression and activation of STAT3 or be regulated by STAT3. The figure shows the specific ncRNAs with clear mechanisms mentioned in the text