Table 1.
MiRNAs involved in STAT3 signaling pathway
| MicroRNA | Up-/down-regulation | Role in glioma | Biological functions | Target gene | Refs. |
|---|---|---|---|---|---|
| miR cluster MC‐let‐7a‐1 ~ let‐7d | Down | Tumor suppressor | Inhibit proliferation, promote apoptosis, and cell autophagy | STAT3 | [40] |
| miR-506 | Down | Tumor suppressor | Inhibit proliferation, migration, and invasion | STAT3 | [42] |
| miR-181d | Down | Tumor suppressor | Inhibit migration and invasion | STAT3/STAT5A | [43] |
| miR-29b | Down | Tumor suppressor | Inhibit chemoresistance | STAT3 | [45] |
| miR-519a | Down | Tumor suppressor | Inhibit proliferation, migration, invasion, and chemoresistance | STAT3 | [46, 47] |
| miR-124 | Down | Tumor suppressor | Inhibit proliferation, promote apoptosis, and immune therapeutics | STAT3/SAMD4 | [48, 56] |
| miR‐221/222 cluster | Up | Oncogene | Promote migration, invasion, proliferation, and angiogenesis | SOCS3 | [50] |
| miR-30 | Up | Oncogene | Promote tumorigenesis | SOCS3 | [51] |
| miR-125b | Up | Oncogene | Promote chemoresistance | PIAS3 | [53] |
| miR-133a | Down | Tumor suppressor | Inhibit proliferation, migration, and invasion, promote apoptosis | CTGF | [55] |
| miR-148a | Up | Oncogene | Promote migration, invasion | CADM1 | [58] |
| miR-876-3p | Down | Tumor suppressor | Inhibit proliferation, migration, and invasion | KIF20A | [60] |
| miR-26a | Up | Oncogene | Promote chemoresistance, migration, invasion, proliferation | AP-2α | [62] |
| miR-6743-5p | Up | Oncogene | Promote proliferation, inhibit apoptosis | GRIM-19 | [63] |
| miR-1246 | Up | Oncogene | Promote proliferation, migration, and invasion | TERF2IP | [65] |
| miR-125b/miR-20b | Up | Oncogene | Promote proliferation | FZD6/ALDH1A3 | [67] |
| miR-21 | Up | Oncogene | Promote proliferation and invasion | RECK | [68, 69, 70, 71] |
| miR-182-5p | Up | Oncogene | Promote proliferation, migration, and invasion | PCDH8 | [72] |
| miR-30b-3p | Up | Oncogene | Promote proliferation, chemoresistance, and inhibit apoptosis | RHOB | [73] |
| miR-218 | Down | Tumor suppressor | Inhibits proliferation | PDGFRα | [74] |
| miR-34a | Down | Tumor suppressor | Inhibit migration and invasion | – | [75] |
| miR-184 | Up | Oncogene | Promote proliferation and invasion | – | [76] |
| miR-203 | Down | Tumor suppressor | Radiosensitivity | – | [77] |
| miR-31 | Down | Tumor suppressor | Promote apoptosis | – | [78] |
| miR-27b | Up | Oncogene | Promote invasion, proliferation, inhibit apoptosis | – | [79] |
| miR-302/367 | Down | Tumor suppressor | Inhibit proliferation, migration | – | [80] |