Fig. 3.

IUE pHGG and DMG mouse models recapitulate PDX tumor-associated vascular differences. a Representative immunofluorescent z-stack projection images of CD31-positive blood vessels in each experimental condition. Scale bar = 20 μm. Quantification of b CD31-positive blood vessel diameter, c density and d branch points. Control cortex and brainstem groups (n = 3), IUE DMG (n = 6) and IUE pHGG (n = 4). Data are presented as mean ± SEM. ***p < 0.0001; unpaired t-test with Mann–Whitney posthoc comparison