Table 1.
A list of different tauopathies and their cell type-specific tau lesions
| Tauopathy | Tau lesions | |||
|---|---|---|---|---|
| Disorder | Predominant tau isoform | Neuron | Astrocyte | Oligodendrocyte |
| PiD | 3R | Pick bodies (+++) and Ballooned neurons (++) | Ramified astrocytes | Pick body-like inclusions |
| PSP | 4R | Neurofibrillary tangles (++) and Pretangles (+++) | Tufted astrocytes | Coiled bodies(+++) |
| CBD | 4R | Pretangles (+++) and Ballooned neurons(++) | Astrocytic plaques | Coiled bodies(++) |
| GGT | 4R | Pretangles (+++) | Globular astrocytic inclusions | Globular oligodendroglial inclusions |
| AGD | 4R | Grains (+++) and Ballooned neurons(+) | Ramified (bushy) astrocytes | Coiled bodies(+) |
| PART | 3R/4R | Neurofibrillary tangles | N/A | N/A |
| ARTAG | 4R | N/A | Thorn-shaped and Granular fuzzy astrocytes | N/A |
| AD | 3R/4R | Neurofibrillary tangles (+++) | N/A | N/A |
| CTE | 3R/4R | Neurofibrillary tangles (++) | Thorn-shaped astrocytes | N/A |
Abbreviations: +: mild; ++: moderate; +++: marked; N/A not applicable