Table 2.
A list of transgenic mouse models showing tau lesions in non-neuronal cell types
| Name (if applicable) | Human tau isoform | Mutation (if applicable) | Promoter | Type of p-tau + cells | Ref. |
|---|---|---|---|---|---|
| TG23 | 0N3R | WT | HMG-CR | Neuron, astro | [173] |
| - | 2N4R | p.G272V | mPrP-tTA | Neuron, olig | [174] |
| JNPL3 | 0N4R | p.P301L | mPrP | Neuron, astro, olig | [175, 176] |
| rTg4510 | 0N4R | p.P301L | CaMKII-tTA | Neuron, olig | [177, 178] |
| Tα1-3RT tau Tg | 0N3R,1N3R, 2N3R | WT | mTα1α-tubulin | Astro, olig | [179] |
| T-279 | 2N4R | p.N279K | hTau | Neuron, astro | [180] |
| GFAP/tauWT | 1N4R | WT | GFAP | Astro | [115, 181] |
| GFAP/tauP301L | 1N4R | p.P301L | GFAP | Astro | [115] |
| - | 1N4R | WT or p.P301L | mCNP | Olig | [182] |
Abbreviations: astro astrocyte; CaMKII calcium/calmodulin kinase IIα promoter; GFAP Glial fibrillary acidic protein; HMG-CR HMG-CoA reductase; hTau human tau; mCNP mouse 2', 3'-cyclic nucleotide 3'-phosphodiesterase; mPrP mouse prion; olig oligodendrocyte; tTA tetracycline-responsive transactivator; WT wild-type