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TRIM18 knockdown inhibits HG-induced epithelial–mesenchymal transition (EMT), inflammation, and fibrosis. (A–C) TRIM18 expression in HG-treated HK-2 cells. TRIM18-silenced HK-2 cells were treated with HG, and then the (D) cell morphology, (E–G) levels of IL-6, TNF-α, and Hyp, and (H,I) expression of p-STAT3, TRIM18, CTGF, and α-SMA were measured. Scale bar: 100 μm. Values are presented as mean ± SD. n = 3/group. ***p < 0.001 vs. NG. ###p < 0.001 vs. HG+shNC.
