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. 2021 Aug 9;11:697247. doi: 10.3389/fonc.2021.697247

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Copyright © 2021 Li, Wang, Chen, Cao, Zhang, Gu, Qi, Fei, Shi, Li, Li, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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“Compound-target-metabolite” interactive network construction for the effects of anlotinib and XHW in the treatment of lung cancer. (A) Direct target information regulating metabolites. (B) Anlotinib and the chemical components of Xihuang Pills coregulate the metabolite network through direct targets. The purple dots represent the targets associated with potential metabolites. The yellow dots represent potential metabolites. The red square and red triangles represent anlotinib and the chemical components of XHW, respectively.