Table 1.
Differential metabolites and the corresponding pathways.
| No. | Retention time(min) | Metabolites | m/z | Model vs Normal | Anlotinib/XHW vs Model | Pathways |
|---|---|---|---|---|---|---|
| 1 | 3.245 | Aminoimidazole ribonucleotide | 295.06 | ↓ | ↑ | Purine metabolism |
| 2 | 3.36 | Creatine | 131.07 | ↑ | ↓ | Glycine, serine and threonine metabolism Arginine and proline metabolism |
| 3 | 3.5 | Adrenaline | 183.09 | ↓ | ↑ | Tyrosine metabolism |
| 4 | 3.736 | Indolepyruvate | 203.06 | ↓ | ↑ | Tryptophan metabolism |
| 5 | 7.986 | Tryptophan | 204.09 | ↓ | ↑ | Tryptophan metabolism |
| Aminoacyl-tRNA biosynthesis | ||||||
| 6 | 22.693 | Lactosylceramide | 805.56 | ↑ | ↓ | Sphingolipid metabolism |
| 7 | 20.754 | LysoPC 18:1(9Z) | 521.35 | ↓ | ↑ | Glycerophospholipid metabolism |
| 8 | 22.148 | Arachidonic acid | 304.24 | ↑ | ↓ | Biosynthesis of unsaturated fatty acids Arachidonic acid metabolism |
| 9 | 22.678 | Farnesylcysteine | 325.21 | ↓ | ↑ | Terpenoid backbone biosynthesis |
| 10 | 22.709 | Linoleic acid | 280.24 | ↑ | ↓ | Biosynthesis of unsaturated fatty acids linoleic acid metabolism |
| 11 | 23.906 | Phytosphingosine | 317.29 | ↓ | ↑ | Sphingolipid metabolism |
| 12 | 24.225 | Palmitic acid (Hexadecanoic acid) | 256.24 | ↑ | ↓ | Biosynthesis of unsaturated fatty acids |
| Fatty acid elongation | ||||||
| Fatty acid degradation | ||||||
| Fatty acid biosynthesis |